Gene

vcp

ID

ZDB-GENE-030131-5408

Name

valosin containing protein

Symbol

vcp Nomenclature History

Previous Names

CDC48 (1)
wu:fd16d05
wu:fj63d11

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to localize to several cellular components, including VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and site of double-strand break. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Is expressed in brain; lens; liver; and trunk musculature. Orthologous to human VCP (valosin containing protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56043 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vcp Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2Y	Alliance	Charcot-Marie-Tooth disease, type 2Y	616687
frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Alliance	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	613954
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1	Alliance	Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1	167320

Associated With vcp Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003338	CDC48, N-terminal subdomain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR004201	CDC48, domain 2
Domain	IPR015415	Spastin/Vps4, C-terminal
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005938	AAA ATPase, CDC48 family
Homologous_superfamily	IPR009010	Aspartate decarboxylase-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029067	CDC48 domain 2-like superfamily

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA ATPase, CDC48 family	AAA+ ATPase domain	Aspartate decarboxylase-like domain superfamily	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	CDC48, domain 2	CDC48 domain 2-like superfamily	CDC48, N-terminal subdomain	P-loop containing nucleoside triphosphate hydrolase	Spastin/Vps4, C-terminal
UniProtKB:Q7ZU99 InterPro	806

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vcp-201 (1) Ensembl	Havana	3041 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-004 (1) Ensembl	Havana	594 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-006 (1) Ensembl	Havana	418 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-007 (1) Ensembl	Havana	686 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-008 (1) Ensembl	Havana	671 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-009 (1) Ensembl	Havana	703 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-010 (1) Ensembl	Havana	697 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vcp-011 (1) Ensembl	Havana	598 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-vcp	polyclonal	vcp	IgG	Rabbit		Novus Biologicals, LLC	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations