PUBLICATION
Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish
- Authors
- Leibold, S., Bagivalu Lakshminarasimha, A., Gremse, F., Hammerschmidt, M., Michel, M.
- ID
- ZDB-PUB-220512-15
- Date
- 2022
- Source
- PLoS One 17: e0267933 (Journal)
- Registered Authors
- Hammerschmidt, Matthias, Leibold, Sandra, Michel, Max
- Keywords
- none
- MeSH Terms
-
- Animals
- Diet
- Mammals
- Metabolic Syndrome*/complications
- Obesity/etiology
- Obesity/metabolism
- Phenotype
- Zebrafish*
- PubMed
- 35544474 Full text @ PLoS One
Citation
Leibold, S., Bagivalu Lakshminarasimha, A., Gremse, F., Hammerschmidt, M., Michel, M. (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. PLoS One. 17:e0267933.
Abstract
Obesity and metabolic syndrome are of increasing global concern. In order to understand the basic biology and etiology of obesity, research has turned to animals across the vertebrate spectrum including zebrafish. Here, we carefully characterize zebrafish in a long-term obesogenic environment as well as zebrafish that went through early lifetime caloric restriction. We found that long-term obesity in zebrafish leads to metabolic endpoints comparable to mammals including increased adiposity, weight, hepatic steatosis and hepatic lesions but not signs of glucose dysregulation or differences in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of metabolic syndrome, however fish that were calorically restricted from five days after fertilization until three to nine months of age did not show signs of an exacerbated phenotype. In contrast, the groups that were shifted later in life from caloric restriction to the obesogenic environment did not completely catch up to the long-term obesity group by the end of our experiment. This dataset provides insight into a slowly exacerbating time-course of obesity phenotypes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping