PUBLICATION
Dissection of cardiovascular development and disease pathways in zebrafish
- Authors
- Chan, J., and Mably, J.D.
- ID
- ZDB-PUB-110317-33
- Date
- 2011
- Source
- Progress in molecular biology and translational science 100: 111-153 (Review)
- Registered Authors
- Chan, Joanne, Mably, John
- Keywords
- Zebrafish, Heart, Cardiac, Vascular, Endothelium, Disease models
- MeSH Terms
-
- Animals
- Blood Vessels/pathology
- Blood Vessels/physiopathology
- Cardiovascular Diseases/embryology
- Cardiovascular Diseases/genetics
- Cardiovascular Diseases/pathology*
- Cardiovascular Diseases/physiopathology
- Cardiovascular System/embryology*
- Cardiovascular System/pathology
- Conserved Sequence/genetics
- Disease Models, Animal
- Humans
- Zebrafish/embryology
- Zebrafish/physiology*
- PubMed
- 21377626 Full text @ Prog. Mol. Biol. Transl. Sci.
Citation
Chan, J., and Mably, J.D. (2011) Dissection of cardiovascular development and disease pathways in zebrafish. Progress in molecular biology and translational science. 100:111-153.
Abstract
The use of animal models in medicine has contributed significantly to the development of drug treatments and surgical procedures for the last century, in particular for cardiovascular disease. In order to model human disease in an animal, an appreciation of the strengths and limitations of the system are required to interpret results and design the logical sequence of steps toward clinical translation. As the world's population ages, cardiovascular disease will become even more prominent and further progress will be essential to stave off what seems destined to become a massive public health issue. Future treatments will require the imaginative application of current models as well as the generation of new ones. In this review, we discuss the resources available for modeling cardiovascular disease in zebrafish and the varied attributes of this system. We then discuss current zebrafish disease models and their potential that has yet to be exploited.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping