ZFIN Person: Karlstrom, Rolf

ZFIN ID: ZDB-PERS-960805-286

ZFIN ID: ZDB-PERS-960805-286

Karlstrom, Rolf

Email:	karlstrom@bio.umass.edu
URL:	http://www.bio.umass.edu/biology/faculty/karlstrom.phtml
Affiliation:	Karlstrom Lab
Address:	Biology Department University of Massachusetts Amherst 448 Morrill Science Center 611 North Pleasant Street Amherst, MA 01003 USA
Country:	United States
Phone:	(413) 577-3448
Fax:	(413) 545-3243
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Male, I., Ozacar, A.T., Fagan, R.R., Loring, M.D., Loring, M.D., Shen, M.C., Pace, V.A., Devine, C.A., Lawson, G.E., Lutservitz, A., Karlstrom, R.O. (2020) Hedgehog signaling regulates neurogenesis in the larval and adult zebrafish hypothalamus. eNeuro. 7(6):

Navon, D., Male, I., Tetrault, E.R., Aaronson, B., Karlstrom, R.O., Albertson, R.C. (2020) Hedgehog signaling is necessary and sufficient to mediate craniofacial plasticity in teleosts. Proceedings of the National Academy of Sciences of the United States of America. 117(32):19321-19327

Tonyushkina, K., Krug, S., Ortiz-Toro, T., Mascari, T., Karlstrom, R. (2017) Low thyroid hormone levels disrupt thyrotrope development. Endocrinology. 158(9):2774-2782

Breves, J.P., McCormick, S.D., and Karlstrom, R.O. (2014) Prolactin and teleost ionocytes: New insights into cellular and molecular targets of prolactin in vertebrate epithelia. General and comparative endocrinology. 203C:21-28

Tonyushkina, K.N., Shen, M.C., Ortiz-Toro, T., and Karlstrom, R.O. (2014) Embryonic exposure to excess thyroid hormone causes thyrotrope cell death. J. Clin. Invest.. 124(1):321-327

Shen, M., Ozacar, A.T., Osgood, M., Boeras, C., Pink, J., Thomas, J., Kohtz, J., and Karlstrom, R.O. (2013) Heat-shock–mediated conditional regulation of hedgehog/gli signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(5):539-49

Breves, J.P., Serizier, S.B., Goffin, V., McCormick, S.D., and Karlstrom, R.O. (2013) Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill. Molecular and Cellular Endocrinology. 369(1-2):98-106

Choi, W.Y., Gemberling, M., Wang, J., Holdway, J.E., Shen, M.C., Karlstrom, R.O., and Poss, K.D. (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development (Cambridge, England). 140(3):660-666

Bergeron, S.A., Tyurina, O.V., Miller, E., Bagas, A., and Karlstrom, R.O. (2011) Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish. Development (Cambridge, England). 138(1):75-85

Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618

Gates, K.P., Mentzer, L., Karlstrom, R.O., and Sirotkin, H.I. (2010) The transcriptional repressor REST/NRSF modulates hedgehog signaling. Developmental Biology. 340(2):293-305

Placinta, M., Shen, M.C., Achermann, M., and Karlstrom, R.O. (2009) A laser pointer driven microheater for precise local heating and conditional gene regulation in vivo. Microheater driven gene regulation in zebrafish. BMC Developmental Biology. 9:73

Wang, Z., Glenn, H., Brown, C., Valavanis, C., Liu, J.X., Seth, A., Thomas, J.E., Karlstrom, R.O., and Schwartz, L.M. (2009) Regulation of muscle differentiation and survival by Acheron. Mechanisms of Development. 126(8-9):700-709

Devine, C.A., Sbrogna, J.L., Guner, B., Osgood, M., Shen, M.C., and Karlstrom, R.O. (2009) A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Developmental Biology. 326(1):143-154

Guner, B., Ozacar, A.T., Thomas, J.E., and Karlstrom, R.O. (2008) Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 149(9):4435-4451

Bergeron, S.A., Milla, L.A., Villegas, R., Shen, M.C., Burgess, S.M., Allende, M.L., Karlstrom, R.O., and Palma, V. (2008) Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos. Genomics. 91(2):165-177

Guner, B., and Karlstrom, R.O. (2007) Cloning of zebrafish nkx6.2 and a comprehensive analysis of the conserved transcriptional response to Hedgehog/Gli signaling in the zebrafish neural tube. Gene expression patterns : GEP. 7(5):596-605

Cerda, G.A., Thomas, J.E., Allende, M.L., Karlstrom, R.O., and Palma, V. (2006) Electroporation of DNA, RNA, and morpholinos into zebrafish embryos. Methods (San Diego, Calif.). 39(3):207-211

Seth, A., Culverwell, J., Walkowicz, M., Toro, S., Rick, J.M., Neuhauss, S.C., Varga, Z.M., and Karlstrom, R.O. (2006) belladonna/(lhx2) is required for neural patterning and midline axon guidance in the zebrafish forebrain. Development (Cambridge, England). 133(4):725-735

Barresi, M.J., Hutson, L.D., Chien, C.B., and Karlstrom, R.O. (2005) Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrain. Development (Cambridge, England). 132(16):3643-3656

Vanderlaan, G., Tyurina, O.V., Karlstrom, R.O., and Chandrasekhar, A. (2005) Gli function is essential for motor neuron induction in zebrafish. Developmental Biology. 282(2):550-570

Tyurina, O.V., Guner, B., Popova, E., Feng, J., Schier, A.F., Kohtz, J.D., and Karlstrom, R.O. (2005) Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Developmental Biology. 277(2):537-556

Feng, J., White, B., Tyurina, O.V., Guner, B., Larson, T., Lee, H.Y., Karlstrom, R.O., and Kohtz, J.D. (2004) Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids. Development (Cambridge, England). 131(17):4357-4370

Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., and Kawakami, A. (2004) The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (Cambridge, England). 131(11):2521-2532

Ungos, J.M., Karlstrom, R.O., and Raible, D.W. (2003) Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Development (Cambridge, England). 130(22):5351-5362

Karlstrom, R.O., Tyurina, O.V., Kawakami, A., Nishioka, N., Talbot, W.S., Sasaki, H., and Schier, A.F. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development (Cambridge, England). 130(8):1549-1564

Sbrogna, J.L., Barresi, M.J., and Karlstrom, R.O. (2003) Multiple roles for Hedgehog signaling in zebrafish pituitary development. Developmental Biology. 254(1):19-35

Culverwell, J. and Karlstrom, R.O. (2002) Making the connection: retinal axon guidance in the zebrafish. Seminars in cell & developmental biology. 13(6):497-506

diIorio, P.J., Moss, J.B., Sbrogna, J.L., Karlstrom, R.O., and Moss, L.G. (2002) Sonic hedgehog is required early in pancreatic islet development. Developmental Biology. 244(1):75-84

Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., and Karlstrom, R.O. (2000) Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Mechanisms of Development. 96(2):165-174

Karlstrom, R.O., Talbot, W.S., and Schier, A.F. (1999) Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes & Development. 13:388-393

Karlstrom, R.O., Trowe, T., and Bonhoeffer, F. (1997) Genetic analysis of axon guidance and mapping in the zebrafish. Trends in neurosciences. 20(1):3-8

Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development (Cambridge, England). 123:427-438

Karlstrom, R.O. and Kane, D.A. (1996) A flipbook of zebrafish embryogenesis. Development (Cambridge, England). 123:461

Baier, H., Klostermann, S., Trowe, T., Karlstrom, R.O., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Genetic dissection of the retinotectal projection. Development (Cambridge, England). 123:415-425

Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England). 123:439-450

Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142

NON-ZEBRAFISH PUBLICATIONS
Karlstrom, R.O., Wilder, L.P., and Bastiani, M.J. (1993) Lachesin: An
immunoglobulin superfamily protein whose expression correlates with
neurogenesis and axon outgrowth in grasshopper embryos. Development
118:509-522.

Desai C.J., Popova E., Zinn K.(1994) A Drosophila receptor tyrosine phosphatase expressed in the embrionic CNS and larval optic lobe is a member of set of proteins bearing the 'HRP' carbohydrate epitope. J.Neurosci.14, 7272-7283

Gorczyca M.G., Popova E., Jia X.-X., Budnik V.(1999) The regulator of chromatin structure gene mod(mdg4) controls synase structure and specificity in Drosophila. In press