ZFIN Image: McMahon et al., 2009, Fig. 11

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Figure Caption

Fig. 11 Lmx1b is required for patterning the retina in a manner partially independent from Fgf signaling. Expression of nasal, temporal, and dorsal ocular markers with reduced Fgf signaling and Lmx1b function. Lateral view of 24 hpf eyes from whole mount in situ hybridization of (panel A) efna5a (nasal), (panel B) eph4b (temporal), and (panel C) tbx5 (dorsal). Note the reduction of efna5a and tbx5 markers in fgf8a/ace mutants or SU5402-treated embryos and expansion of these markers in lmx1b morphants. Partially rescued and intermediate phenotypes were observed when Fgf signaling was reduced in lmx1b morphants. With eph4b, expansion was noted in fgf8a/ace mutants or SU5402-treated embryos, while the opposite was found in lmx1b morphants. Again, intermediate phenotypes were observed when Fgf signaling was reduced in lmx1b morphants.

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Acknowledgments

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Reprinted from Developmental Biology, 332(2), McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A., Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish, 287-298, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.