Gene

otog

ID

ZDB-GENE-120228-1

Name

otogelin

Symbol

otog Nomenclature History

Previous Names

einstein (1)
eis (1)
rks
rock solo (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have alpha-L-arabinofuranosidase activity and structural molecule activity. Involved in otolith formation and otolith tethering. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 18B. Is expressed in otic vesicle and vestibuloauditory system. Orthologous to human OTOG (otogelin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 26 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With otog Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 18B	Alliance	Deafness, autosomal recessive 18B	614945

Associated With otog Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR001846	von Willebrand factor, type D domain
Domain	IPR002919	Trypsin Inhibitor-like, cysteine rich domain
Domain	IPR006207	Cystine knot, C-terminal
Domain	IPR007934	Alpha-L-arabinofuranosidase B, arabinose-binding domain
Domain	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
Homologous_superfamily	IPR036084	Serine protease inhibitor-like superfamily
Homologous_superfamily	IPR036195	Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily

Domain Details Per Protein

Protein	Length	Alpha-L-arabinofuranosidase B, arabinose-binding domain	Alpha-L-arabinofuranosidase B, arabinose-binding domain superfamily	Cystine knot, C-terminal	EGF-like domain	Serine protease inhibitor-like superfamily	Trypsin Inhibitor-like, cysteine rich domain	von Willebrand factor, type D domain	VWFC domain	VWF/SSPO/Zonadhesin-like, cysteine-rich domain
UniProtKB:A0A8M9Q1V8 InterPro	3214

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	otog-201 (1) Ensembl	Havana	764 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	otog-202 (1) Ensembl	Havana	10367 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB1-otog	polyclonal	otog		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations