Gene

tmc1

ID
ZDB-GENE-060526-261
Name
transmembrane channel-like 1
Symbol
tmc1 Nomenclature History
Previous Names
  • si:dkey-229d2.1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have mechanosensitive ion channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound. Localizes to stereocilium bundle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is expressed in anterior crista; inner ear; lateral crista; neuromast; and posterior crista. Orthologous to human TMC1 (transmembrane channel like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Maeda et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Zhu et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tmc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 36 Alliance Deafness, autosomal dominant 36 606705
autosomal recessive nonsyndromic deafness 7 Alliance Deafness, autosomal recessive 7 600974
Associated With tmc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR012496 TMC domain
Family IPR038900 Transmembrane channel-like protein
Domain Details Per Protein
Protein Length TMC domain Transmembrane channel-like protein
UniProtKB:F1QFU0 720
UniProtKB:A0A5H1ZRH9 990
UniProtKB:A0A8M9PKH1 990
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations