Gene

myoc

ID
ZDB-GENE-050425-2
Name
myocilin
Symbol
myoc Nomenclature History
Previous Names
  • zgc:136645
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to be involved in positive regulation of cell migration; regulation of cell-matrix adhesion; and regulation of stress fiber assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Is expressed in caudal fin skeleton; eye; and postcranial axial skeleton. Orthologous to human MYOC (myocilin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from Atienzar-Aroca et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myoc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
juvenile glaucoma Alliance Glaucoma 1A, primary open angle 137750
open-angle glaucoma Alliance Glaucoma 1A, primary open angle 137750
Associated With myoc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003112 Olfactomedin-like domain
Domain Details Per Protein
Protein Length Olfactomedin-like domain
UniProtKB:Q5F0G5 474
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations