Gene

hmcn1

ID

ZDB-GENE-041014-322

Name

hemicentin 1

Symbol

hmcn1 Nomenclature History

Previous Names

nag
nagel (1)
nel (1)
si:ch211-169j21.3

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in basement membrane organization and fin morphogenesis. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Is expressed in several structures, including axis; epidermis; median fin fold; notochord; and pectoral fin. Orthologous to human HMCN1 (hemicentin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu1648 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 30 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmcn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
age related macular degeneration 1	Alliance	{Macular degeneration, age-related, 1}	603075

Associated With hmcn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR006605	G2 nidogen/fibulin G2F
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR026823	Complement Clr-like EGF domain
Homologous_superfamily	IPR009017	Green fluorescent protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	Complement Clr-like EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	G2 nidogen/fibulin G2F	Green fluorescent protein	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Immunoglobulin V-set domain	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily	von Willebrand factor A-like domain superfamily
UniProtKB:A0A8M3AKX8 InterPro	5502
UniProtKB:A0A8M3B479 InterPro	3868
UniProtKB:A0A8M2B7L6 InterPro	5623
UniProtKB:D7PS96 InterPro	5615

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hmcn1-202 (1) Ensembl	Havana	18491 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hmcn1-203 (1) Ensembl	Havana	560 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations