Gene

cnot1

ID

ZDB-GENE-040915-1

Name

CCR4-NOT transcription complex, subunit 1

Symbol

cnot1 Nomenclature History

Previous Names

cdc39-like (1)
im:7141761
kiaa1007l (1)
wu:fc58h04
zgc:152902

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have estrogen receptor binding activity; molecular adaptor activity; and retinoic acid receptor binding activity. Involved in developmental growth. Predicted to localize to CCR4-NOT core complex and P-body. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7141761 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnot1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 12	Alliance	Holoprosencephaly 12, with or without pancreatic agenesis	618500
Vissers-Bodmer syndrome	Alliance	Vissers-Bodmer syndrome	619033

Associated With cnot1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007196	CCR4-Not complex component, Not1, C-terminal
Domain	IPR024557	CCR4-NOT transcription complex subunit 1, domain 4
Domain	IPR032191	CCR4-NOT transcription complex subunit 1, CAF1-binding domain
Domain	IPR032193	CCR4-NOT transcription complex subunit 1, TTP binding domain
Domain	IPR032194	CCR4-NOT transcription complex subunit 1, HEAT repeat
Family	IPR040398	CCR4-NOT transcription complex subunit 1
Homologous_superfamily	IPR038535	CCR4-NOT subunit 1, TTP binding domain superfamily

Domain Details Per Protein

Protein	Length	CCR4-Not complex component, Not1, C-terminal	CCR4-NOT subunit 1, TTP binding domain superfamily	CCR4-NOT transcription complex subunit 1	CCR4-NOT transcription complex subunit 1, CAF1-binding domain	CCR4-NOT transcription complex subunit 1, domain 4	CCR4-NOT transcription complex subunit 1, HEAT repeat	CCR4-NOT transcription complex subunit 1, TTP binding domain
UniProtKB:A1A5H6 InterPro	2374

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cnot1-201 (1) Ensembl	Havana	8236 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cnot1-202 (1) Ensembl	Havana	879 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cnot1-003 (1) Ensembl	Havana	791 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cnot1-004 (1) Ensembl	Havana	847 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations