Gene
rnaseh1
- ID
- ZDB-GENE-040718-407
- Name
- ribonuclease H1
- Symbol
- rnaseh1 Nomenclature History
- Previous Names
-
- zgc:91971
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and RNA phosphodiester bond hydrolysis, endonucleolytic. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2. Orthologous to human RNASEH1 (ribonuclease H1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2 | Alliance | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 | 616479 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002156 | Ribonuclease H domain |
| Domain | IPR011320 | Ribonuclease H1, N-terminal |
| Family | IPR017067 | Ribonuclease H1, eukaryote |
| Homologous_superfamily | IPR009027 | Large ribosomal subunit protein bL9/RNase H1, N-terminal |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR037056 | Ribonuclease H1, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Large ribosomal subunit protein bL9/RNase H1, N-terminal | Ribonuclease H1, eukaryote | Ribonuclease H1, N-terminal | Ribonuclease H1, N-terminal domain superfamily | Ribonuclease H domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1N0V4
|
297 | |||||||
|
UniProtKB:Q6DG94
|
276 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
rnaseh1-201
(1)
|
Havana | 1281 nt | |
| mRNA |
rnaseh1-202
(1)
|
Havana | 835 nt | |
| ncRNA |
rnaseh1-003
(1)
|
Havana | 535 nt |
Interactions and Pathways
No data available
Plasmids
No data available