Gene

nubpl

ID

ZDB-GENE-040718-140

Name

nucleotide binding protein-like

Symbol

nubpl Nomenclature History

Previous Names

zgc:92633 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and mitochondrial respiratory chain complex I assembly. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Orthologous to human NUBPL (nucleotide binding protein like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6897069 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nubpl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 21	Alliance	Mitochondrial complex I deficiency, nuclear type 21	618242

Associated With nubpl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000808	Iron-sulfur cluster carrier protein-like, conserved site
Family	IPR019591	Mrp/NBP35 ATP-binding protein
Family	IPR033756	Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
Family	IPR044304	Iron-sulfur protein NUBPL-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase