Gene

cyp26b1

ID

ZDB-GENE-030131-2908

Name

cytochrome P450, family 26, subfamily b, polypeptide 1

Symbol

cyp26b1 Nomenclature History

Previous Names

dol
fc21d03
stocksteif (1)
wu:fc21d03
wu:fc26h10
zgc:76999

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have C-22 sterol desaturase activity and retinoic acid 4-hydroxylase activity. Involved in several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and retinoic acid catabolic process. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Is expressed in several structures, including brain; cranium; hindbrain neural keel; pectoral fin; and pleuroperitoneal region. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

44 figures from 29 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 24 figures from 9 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp26b1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Craniosynostosis with radiohumeral fusions and other skeletal and craniofacial anomalies	614416

Associated With cyp26b1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
osteochondrodysplasia	cyp26b1^{ti230g/ti230g}	standard conditions	Laue et al., 2011
craniosynostosis	cyp26b1^{t24295/t24295}	standard conditions	Laue et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002403	Cytochrome P450, E-class, group IV
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group IV	Cytochrome P450 superfamily
UniProtKB:A0A0R4I9F4 InterPro	511
UniProtKB:Q6EIG3 InterPro	511

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyp26b1-201 (1) Ensembl	Havana	3869 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cyp26b1-002 (1) Ensembl	Havana	579 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations