PUBLICATION
Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish
- Authors
- Lee, H.B., Shams, S., Dang Thi, V.H., Boyum, G.E., Modhurima, R., Hall, E.M., Green, I.K., Cervantes, E.M., Miguez, F.E., Clark, K.J.
- ID
- ZDB-PUB-240403-7
- Date
- 2024
- Source
- Scientific Reports 14: 77597759 (Journal)
- Registered Authors
- Clark, Karl, Lee, Han B.
- Keywords
- GAM (generalized additive models), GR (glucocorticoid receptor), Light adaptation, Light assays, Stress response, Zebrafish
- MeSH Terms
-
- Adaptation, Psychological
- Animals
- Hypothalamo-Hypophyseal System*/metabolism
- Larva/genetics
- Larva/metabolism
- Pituitary-Adrenal System/metabolism
- Receptors, Glucocorticoid/genetics
- Receptors, Glucocorticoid/metabolism
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 38565594 Full text @ Sci. Rep.
Citation
Lee, H.B., Shams, S., Dang Thi, V.H., Boyum, G.E., Modhurima, R., Hall, E.M., Green, I.K., Cervantes, E.M., Miguez, F.E., Clark, K.J. (2024) Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish. Scientific Reports. 14:77597759.
Abstract
The vertebrate stress response (SR) is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and contributes to generating context appropriate physiological and behavioral changes. Although the HPA axis plays vital roles both in stressful and basal conditions, research has focused on the response under stress. To understand broader roles of the HPA axis in a changing environment, we characterized an adaptive behavior of larval zebrafish during ambient illumination changes. Genetic abrogation of glucocorticoid receptor (nr3c1) decreased basal locomotor activity in light and darkness. Some key HPI axis receptors (mc2r [ACTH receptor], nr3c1), but not nr3c2 (mineralocorticoid receptor), were required to adapt to light more efficiently but became dispensable when longer illumination was provided. Such light adaptation was more efficient in dimmer light. Our findings show that the HPI axis contributes to the SR, facilitating the phasic response and maintaining an adapted basal state, and that certain adaptations occur without HPI axis activity.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping