PUBLICATION

Transcription factors interact with RNA to regulate genes

Authors

Oksuz, O., Henninger, J.E., Warneford-Thomson, R., Zheng, M.M., Erb, H., Vancura, A., Overholt, K.J., Hawken, S.W., Banani, S.F., Lauman, R., Reich, L.N., Robertson, A.L., Hannett, N.M., Lee, T.I., Zon, L.I., Bonasio, R., Young, R.A.

ID

ZDB-PUB-230705-34

Date

2023

Source

Molecular Cell 83(14): 2449-2463.e13 (Journal)

Registered Authors

Zon, Leonard I.

Keywords

RNA, RNA-binding proteins, arginine-rich motif, chromatin, development, gene regulation, single-molecule imaging, transcription factor, zebrafish

MeSH Terms

Binding Sites
DNA/genetics
Protein Binding
RNA*/metabolism
Transcription Factors*/metabolism

PubMed

37402367 Full text @ Mol. Cell

Abstract

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's identity. The canonical TF accomplishes this with two domains, one that binds specific DNA sequences and the other that binds protein coactivators or corepressors. We find that at least half of TFs also bind RNA, doing so through a previously unrecognized domain with sequence and functional features analogous to the arginine-rich motif of the HIV transcriptional activator Tat. RNA binding contributes to TF function by promoting the dynamic association between DNA, RNA, and TF on chromatin. TF-RNA interactions are a conserved feature important for vertebrate development and disrupted in disease. We propose that the ability to bind DNA, RNA, and protein is a general property of many TFs and is fundamental to their gene regulatory function.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Oksuz et al., 2023 ZDB-PUB-230705-34 PMID:37402367

Transcription factors interact with RNA to regulate genes

Oksuz et al., 2023

ZDB-PUB-230705-34
PMID:37402367