PUBLICATION
The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows
- Authors
- Zúñiga Mouret, R., Greenbaum, J.P., Doll, H.M., Brody, E.M., Iacobucci, E.L., Roland, N.C., Simamora, R.C., Ruiz, I., Seymour, R., Ludwick, L., Krawitz, J.A., Groneberg, A.H., Marques, J.C., Laborde, A., Rajan, G., Del Bene, F., Orger, M.B., Jain, R.A.
- ID
- ZDB-PUB-240329-17
- Date
- 2024
- Source
- iScience 27: 109455109455 (Journal)
- Registered Authors
- Del Bene, Filippo, Jain, Roshan, Orger, Mike, Rajan, Gokul
- Keywords
- Behavioral neuroscience, Molecular biology, Molecular neuroscience, Neuroscience
- MeSH Terms
- none
- PubMed
- 38550987 Full text @ iScience
Citation
Zúñiga Mouret, R., Greenbaum, J.P., Doll, H.M., Brody, E.M., Iacobucci, E.L., Roland, N.C., Simamora, R.C., Ruiz, I., Seymour, R., Ludwick, L., Krawitz, J.A., Groneberg, A.H., Marques, J.C., Laborde, A., Rajan, G., Del Bene, F., Orger, M.B., Jain, R.A. (2024) The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows. iScience. 27:109455109455.
Abstract
Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions, such as the autism-linked ap2s1 gene which supports acoustically evoked habituation learning. ap2s1 encodes an AP2 endocytosis adaptor complex subunit, although its behavioral mechanisms and importance have been unclear. Here, we show that multiple AP2 subunits regulate acoustically evoked behavior selection and habituation learning in zebrafish. Furthermore, ap2s1 biases escape behavior choice in sensory modality-specific manners, and broadly regulates action selection across sensory contexts. We demonstrate that the AP2 complex functions acutely in the nervous system to modulate acoustically evoked habituation, suggesting several spatially and/or temporally distinct mechanisms through which AP2 regulates escape behavior selection and performance. Altogether, we show the AP2 complex coordinates action selection across diverse contexts, providing a vertebrate model for ap2s1's role in human conditions including autism spectrum disorder.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping