PUBLICATION
What can we learn about fish neutrophil and macrophage response to immune challenge from studies in zebrafish
- Authors
- Speirs, Z.C., Loynes, C.A., Mathiessen, H., Elks, P.M., Renshaw, S.A., Jørgensen, L.V.G.
- ID
- ZDB-PUB-240313-5
- Date
- 2024
- Source
- Fish & shellfish immunology 148: 109490 (Journal)
- Registered Authors
- Elks, Philip, Loynes, Catherine, Renshaw, Steve A.
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Immunity, Innate
- Larva
- Macrophages
- Mammals
- Neutrophils*
- Zebrafish*
- PubMed
- 38471626 Full text @ Fish Shellfish Immunol.
Citation
Speirs, Z.C., Loynes, C.A., Mathiessen, H., Elks, P.M., Renshaw, S.A., Jørgensen, L.V.G. (2024) What can we learn about fish neutrophil and macrophage response to immune challenge from studies in zebrafish. Fish & shellfish immunology. 148:109490.
Abstract
Fish rely, to a high degree, on the innate immune system to protect them against the constant exposure to potential pathogenic invasion from the surrounding water during homeostasis and injury. Zebrafish larvae have emerged as an outstanding model organism for immunity. The cellular component of zebrafish innate immunity is similar to the mammalian innate immune system and has a high degree of sophistication due to the needs of living in an aquatic environment from early embryonic stages of life. Innate immune cells (leukocytes), including neutrophils and macrophages, have major roles in protecting zebrafish against pathogens, as well as being essential for proper wound healing and regeneration. Zebrafish larvae are visually transparent, with unprecedented in vivo microscopy opportunities that, in combination with transgenic immune reporter lines, have permitted visualisation of the functions of these cells when zebrafish are exposed to bacterial and parasitic infections, as well as during injury and healing. Recent findings indicate that leukocytes are even more complex than previously anticipated and are essential for inflammation, infection control, and subsequent wound healing and regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping