PUBLICATION
Au/Ag Nanobox-Based Near-Infrared Surface-Enhanced Raman Scattering for Hydrogen Sulfide Sensing
- Authors
- Wang, P., Lux, L., Jin, M., Wan, Y., Wang, W., Hung, C.T., Albaqami, F.H., El-Toni, A.M., Alhoshan, M.S., Li, X., Zhang, F.
- ID
- ZDB-PUB-220113-1
- Date
- 2019
- Source
- ACS applied bio materials 2: 417-423 (Journal)
- Registered Authors
- Zhang, Fan
- Keywords
- Au/Ag nanoboxes, NIR SERS, hydrogen sulfide
- MeSH Terms
- none
- PubMed
- 35016304 Full text @ ACS Appl Bio Mater
Citation
Wang, P., Lux, L., Jin, M., Wan, Y., Wang, W., Hung, C.T., Albaqami, F.H., El-Toni, A.M., Alhoshan, M.S., Li, X., Zhang, F. (2019) Au/Ag Nanobox-Based Near-Infrared Surface-Enhanced Raman Scattering for Hydrogen Sulfide Sensing. ACS applied bio materials. 2:417-423.
Abstract
Hydrogen sulfide (H2S) is a gaseous signaling agent that has important regulatory roles in many biological systems but remains difficult to measure in living biological specimens. Herein, we report a novel near-infrared (NIR) activated surface-enhanced Raman scattering (SERS) nanosensor for in vitro and in vivo H2S assay utilizing Au/Ag alloy nanoboxes with local surface plasmon resonance (LSPR) at 741 nm. This detection is realized by SERS spectrum changes of the NIR probes, which are labeled on Au/Ag nanoboxes under NIR laser irradiation, resulting from the reaction of H2S with Ag in the substrate of Au/Ag nanoboxes. Owing to the well-matching between the incident laser light frequency and the LSPR of the substrates at the NIR region, this SERS nanosensor with a high selectivity and sensitivity can be utilized to monitor the distribution of H2S in living cells and zebrafish embryos. Noticeably, the NIR SERS signal is detectable in tissues at depths of up to 12 mm, demonstrating its huge potential in the in vivo studies of pathophysiological processes involving H2S.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping